The aim of this PhD project is to gain a fundamental understanding of the interaction of a range of ‘intelligent’ delivery systems with various cellular/sub-cellular membranes. Specifically, the project will combine the use of a variety of interfacial techniques, including neutron reflectometry and ellipsometry, to achieve this understanding. Four advanced delivery systems, namely lipid nanoparticles, polymeric nanoparticles, vesicles and nanoemulsions will be examined by studying their interaction of lipid monolayers mimicking the composition of the various cell and sub-cellular membranes. Significantly, the results of the study will be used to aid in the design of improved delivery systems to target the desired intracellular site of action. This PhD project will, therefore, offer a unique opportunity to translate fundamental studies into pharmaceutical development through mechanistic understanding of biological systems.
More details about the application procedure on www.innovaxn.eu/for-students/documents/
The successful candidate will be enrolled in the doctoral school at the University of Manchester (UK), although he/she will be based full-time in the Large Scales Structures group at the Institut Laue-Langevin (Grenoble, France). Here the world leading neutron reflectometer FIGARO is situated as well as a suite of complementary techniques in the Partnership for Soft Condensed Matter. A secondment for a period of 3 months in AstraZeneca, (Cambridge, UK) will be arranged for the student.
More details on the InnovaXN programme on www.innovaxn.eu
InnovaXN is a Horizon 2020 MSCA COFUND programme providing an opportunity for 40 industrial companies to work with 40 PhD students, performing advanced research and exploiting the unique characterisation techniques of the ESRF and ILL. Through collaborations with industry, innovation will be the central theme of the programme. This will provide a unique cross academic-industry science setting, secondment opportunities and society-relevant research, training the future key researchers able to tackle major research and societal challenges.