The quest for novel drug delivery vehicles is increasing in importance, especially considering personalized medicine and emerging drug modalities. Long-lasting drug delivery with tailored release kinetics is still challenging. In this project we aim to generate fundamental knowledge for the tailoring of such platforms based on supramolecular gels.
Supramolecular gels are based on small organic molecule gelators macroscopically immobilizing the solvent at concentrations well below 1 wt%. However, solvent and drug molecules diffuse on the microscopic level with variable impact of the gel fibre network. Using spectroscopy accessing the diffusion dynamics of solvent and drug molecules on different timescales and connecting this with macroscopic drug release kinetics and gel rheology will enable us to tailor diffusion and drug release kinetics from these gels.
You will join the spectroscopy group at the ILL as PhD student of the University of Manchester and primarily employ neutron spectroscopy in this project. This is complemented by techniques such as small angle scattering to probe the gel structure, and nuclear magnetic resonance spectroscopy for longer diffusion timescales.
The project runs in collaboration with our industrial project partner AstraZeneca, UK, and you will be placed with the partner for 3 months for drug release studies.
Further information may be obtained from Katharina Edkins (tel.: +44 (0)161 275 8348, email: email@example.com) and from Tilo Seydel (+33 (0)4 76 20 75 79, email: firstname.lastname@example.org).
More details about the application procedure on www.innovaxn.eu/for-students/documents/
The successful candidate will be enrolled at the doctoral academy of the University of Manchester as part of the Division of Pharmacy and based full-time at the ILL (Grenoble, France), other than a 3-month secondment at Astra-Zeneca in Macclesfield, UK. 3 months of the degree will be held at the University of Manchester for training purposes. Furthermore, a varied pedagogical training programme will be offered to the successful candidate throughout the 3-year PhD project.
More details on the InnovaXN programme on www.innovaxn.eu
InnovaXN is a Horizon 2020 MSCA COFUND programme providing an opportunity for 40 industrial companies to work with 40 PhD students, performing advanced research and exploiting the unique characterisation techniques of the ESRF and ILL. Through collaborations with industry, innovation will be the central theme of the programme. This will provide a unique cross academic-industry science setting, secondment opportunities and society-relevant research, training the future key researchers able to tackle major research and societal challenges.