Thesis subject: Mechanistic and Structural Studies of Fatty Acid Metabolism Enzymes using Time-Resolved Serial Crystallography
The aim of this project is to investigate the dynamic behaviour of very long-chain acyl-CoA dehydrogenase (VLCAD) through time-resolved serial crystallography (TR-SSX) to understand the kinetic and structural bases of the fatty acid oxidation (FAO) mechanism. It will provide crucial insights into their mechanistic and structural aspects during catalysis, contributing to the development of targeted therapeutics and the elucidation of pathogenesis in VLCAD deficiencies. Furthermore, this research will enable the development of sample environment methods for TR-SSX in our new flagship beamline ID29. This exciting PhD research opportunity combines cutting-edge synchrotron techniques, collaborative research and the investigation of fundamental biological processes.
Further information may be obtained from M. Soler López (email@example.com) and D. de Sanctis (firstname.lastname@example.org).
Degree allowing enrollment for a PhD (such as MSc, Master 2 de Recherche, Laurea or equivalent) in biophysics, biology or closely related science
● A strong background in structural biology and protein production is desirable
● A strong interest in participating in methods developments for TR-SSX
● Ability to interact with multi-disciplinary staff
● Proficiency in English (working language at the ESRF)
You shall be enrolled in a University / Doctoral School as a condition of your hiring.
Contract of two years renewable for one year.
What we offer:
For further information on employment terms and conditions, please refer to https://www.esrf.fr/home/Jobs/what-we-offer.html
The ESRF is an equal opportunity employer and encourages applications from disabled persons.
The European Synchrotron, the ESRF, is an international research centre based in Grenoble, France.
Through its innovative engineering, pioneering scientific vision and a strong commitment from its 700 staff members, the ESRF is recognised as one of the top research facilities worldwide. Its particle accelerator produces intense X-ray beams that are used by thousands of scientists each year for experiments in diverse fields such as biology, medicine, environmental sciences, cultural heritage, materials science, and physics.
Supported by 21 countries, the ESRF is an equal opportunity employer and encourages diversity.