ESRF - PhD Thesis Student (f/m) on ID30A in the Structural Biology group

At a glance

Job title: PhD Thesis Student (f/m) on ID30A in the Structural Biology group
Ref.: CFR470
Contract type: Time-limited contract
Salary range: 32.7K€
Publication start on Front Office : Site internet: 27/06/2024
Contract duration: 2-year contract, renewable 1 year

Context & Job description

Thesis subject: Exotoxin A from Pseudomonas aeruginosa at MASSIF-1: fragment screening in the era of Artificial Intelligence

Pseudomonas aeruginosa is human pathogen which has been classified by the World Health Organisation as one of the three highest priority antibiotic-resistant bacterias. It is one of the leading causes of hospital-acquired-infections and was responsible for more than half a million deaths in 2019. Central to its virulence exotoxin A protein, which inactivates the host cell translational machinery leading to cell death. In this Ph.D., the successful candidate will identify compounds that modulate the activity of this enzyme using a combination of AI based virtual screening, activity assays, and high throughput x-ray crystallography on the ESRF MX beamlines.

Expected profile

Degree allowing enrollment for a PhD (such as MSc, Master 2 de Recherche, Laurea or equivalent) in biophysics, biology or physics
Background in structural biology is desirable
Ability to interact within a multi-disciplinary team
Proficiency in English (working language at the ESRF)

Working conditions

The salary will be calculated on the basis of relevant qualifications and professional experience.

Do you recognize yourself in this description? Apply now for your next professional adventure!

What we offer:

Join an innovative international research institute, with a workforce from 38 different countries
Collaborate with global experts to advance science and address societal challenges
Come and live in a vibrant city, in the heart of the Alps, and Europe's Green Capital 2022
Enjoy a workplace designed to support your quality of life
Benefit from our competitive compensation and allowances package, including financial support for your relocation to Grenoble

For further information on employment terms and conditions, please refer to https://www.esrf.fr/home/Jobs/what-we-offer.html

The ESRF is an equal opportunity employer and encourages applications from disabled persons.

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Company description

The European Synchrotron, the ESRF, is an international research centre based in Grenoble, France.

Through its innovative engineering, pioneering scientific vision and a strong commitment from its 700 staff members, the ESRF is recognised as one of the top research facilities worldwide. Its particle accelerator produces intense X-ray beams that are used by thousands of scientists each year for experiments in diverse fields such as biology, medicine, environmental sciences, cultural heritage, materials science, and physics.

Supported by 21 countries, the ESRF is an equal opportunity employer and encourages diversity.