PhD Student (f/m) in the Structural Biology group

Thesis subject: Substrate channeling and structural dynamics in vitamin B6 biosynthesis

Substrate channeling and structural dynamics in vitamin B6 biosynthesis probed by high pressure and time-resolved macromolecular crystallography

You will join the Structural Biology Group Groups at the ESRF and the University of Southampton to pursue studies in high-pressure macromolecular crystallography to map gas channels in proteins. Specifically, you will investigate ammonia substrate transport through an internal protein channel in the vitamin B6 biosynthetic enzyme Pdx1 from plants, bacteria or from the malaria causing pathogen Plasmodium. You will combine crystallography at cryogenic temperatures with time resolved studies at room temperature, using serial crystallography and spectroscopic techniques.

Further information may be obtained from Christoph Mueller-Dieckmann (phone: +33 (0)4 76 88 28 70, email: muellerd@esrf.fr), Phillipe Carpentier (phone: +33 (0)4 76 88 27 72, email: philippe.carpentier@esrf.fr) or Ivo Tews (phone: ++44 (0)23-8059-4415, email: Ivo.Tews@soton.ac.uk).